Friday 13 May 2016

URINARY TRACT INFECTION AND PREGNANCY

  •   Urinary tract infections (UTIs) often complicate pregnancy. Precise definitions of UTIs are important. 
  •   A UTI is defined as “the establishment and multiplication of micro-organisms within the urinary tract,” whereas bacteriuria is the detection of bacteria in a voided urine specimen. 
  •   Significant bacteriuria is defined as greater than 1 × 106 of the same organism per milliliter of urine.
  •   Bacteriuria in pregnancy is often asymptomatic.
  •   Cystitis is defined as a symptomatic significant bacteriuria with associated bladder mucosal inflammation, 
  •   Whereas pyelonephritis is defined as symptomatic significant bacteriuria with associated inflammation of the renal parenchyma, calices, and pelvis.
  •   Previous work has established a 5% to 10% prevalence of asymptomatic bacteriuria (ASB) in pregnancy and the association of ASB with the development of symptomatic infections, including pyelonephritis. 
  •   Twenty-five percent to thirty percent of cases of ASB in pregnancy will progress to symptomatic infection. 
  •   This progression from asymptomatic to symptomatic infection with pregnancy is three to fourfold the progression rate in non pregnant females. 
  •   Pyelonephritis has been associated with maternal and fetal morbidity and mortality. Obstetric complications such as preterm labor and low birth weight have been associated with bacteriuria. 
  •   The purpose of this article is to help the physician understand the physiologic changes of the urinary tract associated with pregnancy and the significance of bacteriuria. 
  •   Topics discussed include the screening mechanisms available for bacteriuria in pregnancy and the range of UTIs associated with pregnancy and their treatments
  •   Urinary tract infection is one of the most frequently seen ‘medical’ complications in pregnancy. 
  •   The pioneering work of Edward Kass discovered that 6% of pregnant women had asymptomatic bacteriuria associated with increased prematurity and perinatal mortality compared to women with sterile urine. 
  •   Screening for bacteriuria in pregnancy has become routine. Other factors such as vaginal colonization have been recognized as important contributors to preterm labour. 
  •   The value of screening for bacteriuria has to be re-addressed considering methods, significance and costs. Treatment of urinary tract infection in pregnancy is critically reviewed.
  •   Although pregnancy does not increase the prevalence of asymptomatic bacteruria in women, it does enhance the progression rate from asymptomatic to symptomatic disease.
  •   Symptoms of cystitis include dysuria, hematuria, urinary frequency, urgency or suprapubic discomfort. 
  •   Fever, chills, abdominal pain, flank pain and vomiting are features of pyelonephritis.
  •   Direct microscopy of the urinary sediment for white cells (pyuria), red cells (haematuria), bacteria (bacteruria) and white cells casts is useful to make a diagnosis. 
  •   The urine culture is a sensitive means of detecting asymptomatic bacteruria and provided antibiotic sensitivity.
  •   Treatment in the first trimester is complicated by concerns of possible teratogenicity of drugs. 
  •   Amozycillin, Ampicillin, Amoxycillin with clavunate potassium, cephalosporins are drugs that can be used as first-line therapy in pregnancy.